Phenytoin, metronidazole and multivitamins in the treatment of alcoholismConducted a double-blind study in which 43 male and 7 female 25-58 yr old alcoholics received diphenylhydantoin (DPH), metronidazole (MNZ), or multivitamins (MV) during a 28 day hospitalization and then continued on open medication for 12 mo. Only 7 (6 DPH, 1 MV) Ss continued their medication for the full year. After 4 wks the global rating scale showed noticeable improvement in 8 DPH, 1 MNZ, and no MV Ss, moderate improvement in 6, 3, and 4, respectively, slight improvement in 3, 2, and 7, and no improvement in 3, 4, and 9. WAIS scores showed no significant group differences before treatment; no significant changes occurred after 2 and 4 wks although greater stability was reflected in the scores at 4 wks; nor were there any significant changes in the MMPI scores. Some of the DPH Ss showed improved mood, clarity of thought, ability to maintain attention, ease of falling asleep, increased frustration tolerance, and improved degree and range of social contacts. Based only on clinical impressions, it is concluded that MNZ is valueless for long-term treatment, MV is of value as vitamins only, and DPH has some therapeutic value in some patients because of its nonaddictive properties and its modifying effects on behavior and mood. (26 ref.) ((c) 1997 APA/PsycINFO, all rights reserved)https://www.upress.umn.edu/test-division/bibliography/1970-1979/1972/kaplan_phenytoin_1972https://www.upress.umn.edu/logo.png
R. Kaplan
(1972)
Phenytoin, metronidazole and multivitamins in the treatment of alcoholism
Quarterly Journal of Studies on Alcohol, 33:97 --104.